
2025 - 至今??中國科學(xué)院生物與化學(xué)交叉研究中心,研究員、課題組長
2019 - 2025 ?美國加州大學(xué)伯克利分校/霍華德休斯醫(yī)學(xué)研究所,博士后
2013 - 2019 ?英國牛津大學(xué)醫(yī)學(xué)院,博士及博士后
2009 - 2013 ?北京大學(xué)生命科學(xué)學(xué)院,學(xué)士
張漢林實(shí)驗(yàn)室的主要研究方向?yàn)樯锼ダ?。作為每個(gè)成年個(gè)體都正在親身經(jīng)歷的生命歷程,衰老現(xiàn)象始終激發(fā)著人類深刻的好奇心與同理心。隨著20世紀(jì)末一系列衰老研究奠基性發(fā)現(xiàn)的問世,人類已經(jīng)認(rèn)識(shí)到衰老過程背后存在著復(fù)雜但有規(guī)律、可調(diào)控的分子與細(xì)胞學(xué)機(jī)制。研究這一現(xiàn)象不僅有助于揭示生命運(yùn)行的基本規(guī)律,也在預(yù)防和治療衰老相關(guān)疾病如神經(jīng)退行、癌癥、心腦血管疾病等方面具有重要的應(yīng)用價(jià)值?;谇捌谠诩?xì)胞自噬、線粒體脅迫、胞外基質(zhì)重塑、免疫調(diào)控等衰老相關(guān)領(lǐng)域的積累,本課題組以未配對(duì)的括號(hào)或引號(hào)!細(xì)胞穩(wěn)態(tài)調(diào)控的分子機(jī)制未配對(duì)的括號(hào)或引號(hào)!為核心研究方向,綜合利用線蟲、組織培養(yǎng)、小鼠等多種生物模型,結(jié)合細(xì)胞生物學(xué)、遺傳學(xué)、分子生物學(xué)、免疫學(xué)、多組學(xué)分析等技術(shù)手段,從現(xiàn)象到機(jī)制、從分子到整體對(duì)衰老相關(guān)科學(xué)問題進(jìn)行系統(tǒng)性探索。
具體研究方向包括:
(1)細(xì)胞內(nèi)外穩(wěn)態(tài)的調(diào)節(jié)與通訊機(jī)制;
(2)細(xì)胞穩(wěn)態(tài)信號(hào)通路對(duì)機(jī)體免疫和衰老的調(diào)節(jié);
(3)組織纖維化等衰老相關(guān)病變的發(fā)生與干預(yù)。
(*共同第一作者,#通訊作者)
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