
2005.9-2009.7 中國(guó)藥科大學(xué),學(xué)士
2009.9-2012.8?中國(guó)科學(xué)院上海藥物研究所,碩士
2012.9-2013.7?清華大學(xué),科研助理
2013.9-2018.7 美國(guó)科羅拉多大學(xué)博爾德分校,博士
2018.11-2013.4?耶魯大學(xué),博士后
2023.5-至今 ?中國(guó)科學(xué)院上海有機(jī)化學(xué)研究所生物與化學(xué)交叉研究中心,研究員,課題組長(zhǎng)
通過(guò)發(fā)展和運(yùn)用化學(xué)生物學(xué)的手段來(lái)研究和干預(yù)免疫系統(tǒng)和神經(jīng)系統(tǒng)的疾病發(fā)生發(fā)展過(guò)程,并基于新型的雙功能分子(例如PROTAC和PhosTAC等),進(jìn)行新型藥物的開(kāi)發(fā)。重點(diǎn)研究導(dǎo)致自身免疫系統(tǒng)的過(guò)度激活,以及神經(jīng)退行疾病中的致病蛋白,并開(kāi)發(fā)相關(guān)的抑制劑藥物進(jìn)行疾病治療的探索。
1.?Zhenyi Hu#; Po-Han Chen#; Wenxue Li; Todd Douglas; John Hines; Yansheng Liu; Craig M. Crews. Targeted Dephosphorylation of Tau by Phosphorylation Targeting Chimeras (PhosTACs) as a Therapeutic Modality, Journal of the American Chemical Society, 2023, 145(7): 4045-4055
2.?Hu, Z.?#; Chen, P. H.?#; Li, W.?#; Krone, M.; Zheng, S.; Saarbach, J.; Velasco, I. U.; Hines, J.; Liu, Y.; Crews, C. M. EGFR targeting PhosTACs as a dual inhibitory approach reveals differential downstream signaling. Science?Advances?2024, 10?(13), eadj725
3.?Shuting Zhang#; Zhenyi Hu#; Hiromi Tanji#; Shuangshuang Jiang; Nabanita Das; Jing Li; Kentaro Sakaniwa; Jin Jin; Yanyan Bian; Umeharu Ohto; Toshiyuki Shimizu; Hang Yin. Small-molecule inhibition of TLR8 through stabilization of its resting state, Nature Chemical Biology, 2018, 14(1): 58-64
4.?Zhenyi Hu; Hiromi Tanji; Shuangshuang Jiang; Shuting Zhang; Kyoin Koo; Jean Chan; Kentaro Sakaniwa; Umeharu Ohto; Albert Candia; Toshiyuki Shimizu; Hang Yin. Small-molecule TLR8 antagonists via structure-based rational design, Cell Chemical Biology, 2018, 25(10): 1286-1291
5.?Po-Han Chen#; Zhenyi Hu#; Elvira An; Ifunanya Okeke; Sijin Zheng; Xuanmeng Luo; Angela Gong; Saul Jaime-Figueroa; Craig M. Crews ; Modulation of phosphoprotein activity by phosphorylation targeting chimeras (PhosTACs), ACS Chemical Biology, 2021, 16(12): 2808-2815
6.?Zhenyi Hu; Craig M Crews ; Recent developments in PROTAC-mediated protein degradation: from bench to clinic.,?Chembiochem?: a European journal of chemical biology, 2021, 23(2): e2021002

