
2024.10—至今 中國科學(xué)院上海有機(jī)化學(xué)研究所生物與化學(xué)交叉研究中心,研究員、課題組長
2020.02-2024.09—美國德克薩斯大學(xué)西南醫(yī)學(xué)中心藥學(xué)系?Benjamin Weaver Lab 博士后
2019.05-2019.12—德國慕尼黑大學(xué)Barbara Conradt Lab 初級研究員
2014.10-2019.05—德國慕尼黑大學(xué)Barbara Conradt Lab,博士
2011.09-2014.07—中國科學(xué)院遺傳與發(fā)育生物學(xué)研究所客座研究生(山東農(nóng)業(yè)大學(xué)碩士)?張憲省教授&謝旗研究員,碩士
2007.09-2011.07—山東農(nóng)業(yè)大學(xué),學(xué)士
1. 研究CED-3/caspase(或鑒定其它關(guān)鍵脂質(zhì)代謝調(diào)控因?)如何調(diào)節(jié)脂質(zhì)代謝以消除機(jī)體脂毒性進(jìn)?預(yù)防衰老過程。
2. 揭示CED-3/caspase(或其它關(guān)鍵調(diào)控因?)如何抵抗UV輻射導(dǎo)致的衰?及死亡 。
3. 揭示CED-3/caspase調(diào)控運(yùn)動神經(jīng)元細(xì)胞損傷后的軸突再?修復(fù)機(jī)制。
2023年美國西南醫(yī)學(xué)中心?Alfred & Mabel Gilman Memorial Excellent Post-Doc.?Scientific Research Award
2014年國家公派留學(xué)獎學(xué)金
#co-first authorship *corresponding author
1.?Hai Wei, Yi M. Weaver, Benjamin P. Weaver?2024 Xeroderma pigmentosum protein XPD controls caspase- mediated stress responses. Nature?Communications?PMID:?39472562, DOI:https://doi.org/10.1038/?s41467-024-53755-8
2.?Hai Wei, Yi M. Weaver, Chendong Yang, Yuan Zhang, Guoli Hu, Courtney M. Karner,?Matthew Sieber, Ralph J. DeBerardinis??and Benjamin P. Weaver??2024 Proteolytic Activation of Fatty Acid Synthase Signals Pan-Stress Resolution. Nature Metabolism. PMID: 38167727, DOI: 10.1038/s42255-023-00939-z?(Cover Article, Highlighted and collected by Nature Metabolism)
3.?Aditya Sethi#, Hai Wei#, Nikhil Mishra, Ioannis Segos, Eric J. Lambie, Esther Zanin and Barbara Conradt 2022 A caspase-RhoGEF axis contributes to the cell size threshold for apoptotic death in developing Caenorhabditis elegans. PLOS Biology PMID: 36201522, DOI: 10.1371/journal.pbio.3001786?(#equal contribution)
4.?Hai Wei, Lambie EJ, Oso′rio DS, Carvalho AX, Conradt B. 2020 PIG-1 MELK-dependent phosphorylation of nonmuscle myosin II promotes apoptosis through CES-1 Snail partitioning. PLOS Genetics?PMID: 32946434, DOI: 10.1371/journal.pgen.1008912
5.?W. Deng, Jack A. Bates,?Hai?Wei, Michael D. Bartoschek, Barbara Conradt & Heinrich Leonhardt, 2020 Tunable light and drug induced depletion of target proteins.?Nature?Communications?PMID: 31949141, DOI:10.1038/s41467-019 -14160-8
6.?Mishra N., Hai Wei, and B. Conradt, 2018 Caenorhabditis elegans?ced-3?Caspase Is Required for Asymmetric Divisions That Generate Cells Programmed To Die.?GENETICS?PMID: 30194072, DOI:10.1534/genetics. 118.301500
7.?Hai Wei#, Bo Yan#, J. Gagneur, and B. Conradt, 2017 Caenorhabditis elegans?ces-1?Snail represses pig-1?MELK expression to control asymmetric cell division. GENETICS?PMID: 28652378, DOI:10.1534/genetics.117.202754?(#equal contribution)
8.?Qingliang Li#, Hai Wei#,?Lijing Liu, Xiaoyuan Yang, Xiansheng Zhang, Qi Xie, 2017 Unfolded protein response activation compensates endoplasmic reticulum-associated degradation deficiency in Arabidopsis. Journal of Integrative Plant Biology?PMID: 28418178, DOI: 10.1111/jipb.12544?(#equal contribution)

