教育經(jīng)歷：
2011-2015?慕尼黑大學(xué)/德國神經(jīng)退行性疾病研究中心，博士
2008-2011?重慶大學(xué)，碩士
2004-2008?西南大學(xué)，學(xué)士
工作經(jīng)歷：
2021-至今?中國科學(xué)院生物與化學(xué)交叉中心，課題組長
2016-2021?哈佛大學(xué)醫(yī)學(xué)院，博士后研究員
本課題組專注于研究促進神經(jīng)退行性疾病（包括阿爾茲海默癥、肌萎縮性脊髓側(cè)索硬化癥、腦卒中、多發(fā)性硬化癥等等）病理發(fā)展過程的細(xì)胞分子機理，并基于原創(chuàng)發(fā)現(xiàn)的生物學(xué)問題，設(shè)計相應(yīng)的基因或藥物調(diào)控手段，探索新的神經(jīng)退行性疾病治療方法。
本課題組利用先進的單細(xì)胞分析技術(shù)，長期從事探索多種不同類型中樞神經(jīng)系統(tǒng)細(xì)胞，包括神經(jīng)細(xì)胞、內(nèi)皮細(xì)胞、小膠質(zhì)細(xì)胞、少突膠質(zhì)細(xì)胞、周細(xì)胞、星型膠質(zhì)細(xì)胞和少突膠質(zhì)祖細(xì)細(xì)胞等等，在神經(jīng)退行性疾病不同發(fā)病階段的分子病理變化，重點關(guān)注細(xì)胞凋亡、程序性壞死和炎癥小體激活對神經(jīng)退行性疾病病理進程的影響。
本課題組在探索β淀粉樣蛋白，Tau蛋白和ApoE蛋白等傳統(tǒng)神經(jīng)退行性疾病相關(guān)致病蛋白的新型致病機理和干預(yù)策略的同時，也將利用多種前沿的蛋白質(zhì)組學(xué)，單細(xì)胞測序等技術(shù)，研究心血管和代謝疾病對老年認(rèn)知功能障礙的影響及其作用機制。
1.?????Mifflin, L., Hu, Z., Dufort, C., Hession, C.C., Walker, A.J., Niu, K., Zhu, H., Liu, N., Liu, J.S., Levin, J.Z., Stevens, B., Yuan, J., Zou, C. A RIPK1-Regulated Inflammatory Microglial State in Amyotrophic Lateral Sclerosis. Proc Natl Acad Sci USA, 2021,?In Press.
2.??????Zou, C., Mifflin, L., Hu, Z., Zhang, T., Shan, B., Wang, H., Xing, X., Zhu, H., Adiconis, X., Levin, J.Z., Li, F., Liu, C.-F., Liu, J.S., Yuan, J. Reduction of mNAT1/hNAT2 Contributes to Cerebral Endothelial Necroptosis and Aβ Accumulation in Alzheimer's Disease. Cell Rep, 2020, 33: 108447.
3.??????Zou C., Crux S., Marinesco S., Montagna E., Sgobio C., Shi Y., Shi S., Zhu K., Dorostkar M.M., Müller U.C., Herms J. Amyloid precursor protein maintains constitutive and adaptive plasticity of dendritic spines in adult brain by regulating D-serine homeostasis. EMBO J. 2016, 35: 2213-2222.
4.??????Zou C., Shi Y., Ohli J., Schüller U., Dorostkar M.M., Herms J. Neuroinflammation impairs adaptive structural plasticity of dendritic spines in a preclinical model of Alzheimer's disease. Acta Neuropathol. 2016, 131:235-246.
5.??????Zou C., Montagna E., Shi Y., Peters F., Blazquez-Llorca L., Shi S., Filser S., Dorostkar M.M., Herms J. Intraneuronal APP and extracellular Aβ independently cause dendritic spine pathology in transgenic mouse models of Alzheimer's disease. Acta Neuropathol. 2015, 129:909-20.
6.??????Zou C., Luo Q., Qin J., Shi Y., Yang L., Ju B., Song G. “Osteopontin promotes mesenchymal stem cell migration and lessens cell stiffness via integrin β1, FAK, and ERK pathways”. Cell Biochem Biophys. 2013, 65:455-62.
7.??????Zou C., Song G., Luo Q., Yuan L., Yang L. “Mesenchymal stem cells require integrin β1 for directed migration induced by osteopontin in vitro”. In Vitro Cell Dev Biol Anim. 2011 47:241-50.
8.??????Xu D., Jin T., Zhu H., Chen H., Ofengeim D., Zou C., Mifflin L., Pan L., Amin P., Li W., Shan B., Naito M.G., Meng H., Li Y., Pan H., Aron L., Adiconis X., Levin J.Z., Yankner B.A., Yuan J. “TBK1 suppresses RIPK1-Driven Apoptosis and Inflammation during development and in aging”. Cell. 2018,174:1477-1491.
9.??????Ofengeim D., Mazzitelli S., Ito Y., DeWitt J.P., Mifflin L., Zou C., Das S., Adiconis X., Chen H., Zhu H., Kelliher M.A., Levin J.Z., Yuan J. “RIPK1 mediates a disease associated microglial response in Alzheimer’s disease”. Proc Natl Acad Sci USA. 2017, 114: E8788-E8797.
10.???Ofengeim D., Giagtzoglou N., Huh D., Zou C., Yuan J. “Single-Cell RNA sequencing: unraveling the brain one cell at a time”. Trends Mol Med. 2017, 23:563-576.
11.???Dorostkar M.M., Zou C., Blazquez-Llorca L., Herms J. “Analyzing dendritic spine pathology in Alzheimer’s disease: problems and opportunities”. Acta Neuropathol. 2015, 130:1-19.
