

2006-2010 北京大學化學與分子工程學院?學士
2010-2015 北京大學化學與分子工程學院?博士
2015-2020 美國西北大學?博士后
2020.6-至今?中國科學院上海有機化學研究所 研究員、課題組長
針對生物酶進行設計和應用。一方面,通過對高價值化合物(藥物中間體、化妝品功能食品原料)進行酶催化合成路線設計、酶庫挖掘和定向進化、發(fā)酵放大,實現(xiàn)產(chǎn)業(yè)化生產(chǎn)。另一方面,開發(fā)生物酶作為藥物和保健食品的潛力,并進行設計和優(yōu)化提高生物酶藥物和保健食品的功效。
2021 RSC?Horizon?Prizes?(團隊)
2021 高等學校科學研究優(yōu)秀成果獎(科學技術)一等獎
1. Tongxiao Cui, Yi Man, Feifei Wang, Shuyang Bi, Liang Lin*, Ran Xie*. Glycoenzyme Tool Development: Principles, Screening Methods, and Recent Advances. Chinese Journal of Chemistry 40, 746-758 (2022).
2.?Liang Lin#, Weston Kightlinger#, Adam J. Hockenberry, Michael C. Jewett, and Milan Mrksich. Sequential glycosylation of proteins with substrate-specific N-glycosyltransferases. ACS Central Science?6, 144-154 (2020).
3. Weston Kightlinger#, Liang Lin#, Madisen Rosztoczy, Wenhao Li, Matthew P. DeLisa, Milan Mrksich, and Michael C. Jewett. Design of glycosylation sites by rapid synthesis and analysis of glycosyltransferases. Nature Chemical Biology, 14, 627-635 (2018).
4. Liang Lin#, Ling Liu#, Bing Zhao, Ran Xie, Wei Lin, He Li, Yaya Li, Minlong Shi, Ye-Guang Chen, Timothy A. Springer, and Xing Chen. Carbon nanotube-assisted optical activation of TGF-β signalling by near-infrared light. Nature Nanotechnology 10, 465-471 (2015).
5. Liang Lin#, Xiangdong Tian#, Senlian Hong#, Peng Dai, Qiancheng You, Ruyi Wang, Lianshun Feng, Can Xie, Zhongqun Tian, and Xing Chen.?A bioorthogonal Raman reporter strategy for SERS detection of glycans on live cells. Angewandte Chemie International Edition 52, 7266-7271 (2013).
6. Milan Mrksich, Michael C. Jewett, Liang Lin, Weston Kightlinger. USA Patent, 62545760. August 15th, 2017.
7. Michael C. Jewett, Weston Kightlinger,?Milan Mrksich, Liang Lin.?USA Patent, 63051825. July 14th, 2020.
8. Liang Lin, Long Lv, Yan Jiang, Yaming Wu, Shucheng Song, Lili Sun, Xiaoran Ding. China Patent, ZL201380010573.X. April 26th, 2024.
9. Liang Lin, Ping Wang, Li Li. International Patent,?PCT/CN2024/112335. August 9th, 2024.
10. Xing Chen, Zhongqun Tian, Xiangdong Tian, Liang Lin, Senlian Hong. China Patent, ZL201210342478.3. March 26th, 2014.