1988年9月-1992年7月，四川大學(xué)生物工程系微生物專業(yè),學(xué)士學(xué)位；
1994年9月---1997年7月，中國(guó)協(xié)和醫(yī)科大學(xué)（中國(guó)醫(yī)學(xué)科學(xué)院），碩士學(xué)位；
1997年9月---2000年7月；中國(guó)協(xié)和醫(yī)科大學(xué)（中國(guó)醫(yī)學(xué)科學(xué)院）博士學(xué)位（美國(guó)加州大學(xué)戴維斯分?；瘜W(xué)系聯(lián)合培養(yǎng)）；
2000年9月---2001年8月，美國(guó)加州大學(xué)戴維斯分?；瘜W(xué)系(DepartmentofChemistry,UniversityofCalifornia-Davis)，博士后；
2001年9月---2003年8月，美國(guó)威斯康星大學(xué)麥迪遜分校藥學(xué)院(School of Pharmacy,University of Wisconsin-Madison)，研究助理；
2003年8月-至今，中國(guó)科學(xué)院上海有機(jī)化學(xué)研究所，研究員。
復(fù)雜天然產(chǎn)物的生物合成（遺傳學(xué)、生物化學(xué)和化學(xué)）研究
以產(chǎn)量提高和結(jié)構(gòu)多樣性為目的組合生物合成研究
以基因組挖掘?yàn)槭侄蔚男滦吞烊划a(chǎn)物發(fā)現(xiàn)研究
2019年 上海市自然科學(xué)獎(jiǎng)一等獎(jiǎng)（單位排名第一、個(gè)人排名第一）
2015年 談家楨生命科學(xué)獎(jiǎng)創(chuàng)新獎(jiǎng)
2013年 日本化學(xué)會(huì)The Distinguished Lectureship Award
2010年 明知乳業(yè)生命科學(xué)獎(jiǎng)優(yōu)秀獎(jiǎng)
2008年 上海市科技進(jìn)步獎(jiǎng)一等獎(jiǎng)（單位排名第三、個(gè)人排名第五）
國(guó)家重點(diǎn)研發(fā)計(jì)劃“病原學(xué)與防疫技術(shù)體系研究”重點(diǎn)專項(xiàng)（2022YFC2303100），生物合成研究驅(qū)動(dòng)的新型微生物抗感染藥物創(chuàng)制，2022年12月-2025年11月，項(xiàng)目負(fù)責(zé)人；
國(guó)家自然科學(xué)基金重大項(xiàng)目（22193070），天然產(chǎn)物來源藥物的生物合成與分子創(chuàng)新，2022年01月-2026年12月，項(xiàng)目負(fù)責(zé)人；
國(guó)家自然科學(xué)基金重點(diǎn)項(xiàng)目（32030002），富硫細(xì)菌環(huán)肽類代謝產(chǎn)物的翻譯后修飾、調(diào)控機(jī)制以及結(jié)構(gòu)與功能的多樣性研究，2021年01月-2025年12月，項(xiàng)目負(fù)責(zé)人；
國(guó)家自然科學(xué)基金應(yīng)急管理項(xiàng)目（21750004），大環(huán)天然產(chǎn)物的模板化生物合成及其活性與結(jié)構(gòu)導(dǎo)向的分子創(chuàng)新研究，2018年01月-2020年12月，項(xiàng)目負(fù)責(zé)人；
國(guó)家自然科學(xué)國(guó)際(地區(qū))合作與交流重點(diǎn)項(xiàng)目（21520102004），以多樣性為導(dǎo)向的天然產(chǎn)物生物合成研究，2016年01月-2020年12月，項(xiàng)目負(fù)責(zé)人；
國(guó)家自然科學(xué)基金重點(diǎn)項(xiàng)目（31430005），以活性（抗腫瘤和抗感染）與作用機(jī)制研究為導(dǎo)向的硫肽類抗生素的生物合成，2015年01月-2019年12月，項(xiàng)目負(fù)責(zé)人；
國(guó)家自然科學(xué)基金重點(diǎn)項(xiàng)目（20832009），天然產(chǎn)物獨(dú)特結(jié)構(gòu)單元的生物合成機(jī)制研究，2009年01月-2012年12月，項(xiàng)目負(fù)責(zé)人。
1.???????Botao Cheng#, Jiwu Huang#, Yuting Duan,?Wen Liu*. Association of radical chemistry with LanD flavoprotein activity for?C-terminal macrocyclization of a ribosomal peptide through the formation of an unsaturated thioether residue.?Angewandte Chemie-International Edition?2023,?62(35), e202308733.
2.???????Zhijun Tang#, Bo Pang#, Chang Liu#, Shengjie Guo, Xudong Qu,?Wen Liu*. Formation and loading of a (2S)-2-ethylmalonamyl starter unit in the assembly line of polyketide-nonribosomal peptide hybrid sanglifehrin A.?Angewandte Chemie-International Edition?2023,?62(23), e202217090.
3.???????Hongbo Wang#, Yike Zou#, Miao Li#, Zhijun Tang#, Jiabao Wang, Zhenhua Tian, Nina Strassner, Qian Yang, Qingfei Zheng, Yujiao Guo,?Wen Liu*, Lifeng Pan*, K. N. Houk*. A cyclase that catalyses competing 2 + 2 and 4 + 2 cycloadditions.?Nature Chemistry?2023,?15(2), 177-184.
4.???????Yiyuan Cheng, Xuan Yi, Yan Zhang, Qingli He, Dandan Chen, Weiguo Cao, Pengfei Fang*,?Wen Liu*. Oxidase heterotetramer completes 1？azabicyclo[3.1.0]hexane formation with the association of a nonribosomal peptide synthetase.?Journal of the American Chemical Society?2023,?145(16), 8896-8907.
5.???????Yanqing Xue#, Xiaofeng Wang#,?Wen Liu*. Reconstitution of the linaridin pathway provides access to the family-determining activity of two membrane-associated proteins in the formation of structurally underestimated cypemycin.?Journal of the American Chemical Society?2023,?145(12), 7040-7047.
6.???????Shengjie Guo, Yueqian Sang, Chao Zheng, Xiao-Song Xue, Zhijun Tang*,?Wen Liu*. Enzymatic α？ketothioester decarbonylation occurs in the assembly line of barbamide for skeleton editing.?Journal of the American Chemical Society?2023,?145(9), 5017-5028.
7.???????Ling Hu, Yi Qiao, Jingyu Liu, Chao Zheng, Xiaofeng Wang, Peng Sun, Yucheng Gu,?Wen Liu*. Characterization of histidine functionalization and its timing in the biosynthesis of ribosomally synthesized and posttranslationally modified thioamitides.?Journal of the American Chemical Society?2022,?144(10), 4431-4438.
8.???????Bo Li, Xingyi Guan, Song Yang, Yike Zou,?Wen Liu*, K. N. Houk*. Mechanism of the stereoselective catalysis of Diels？Alderase PyrE3 involved in pyrroindomycin biosynthesis.?Journal of the American Chemical Society?2022,?144(11), 5099-5107.
9.???????Sili Wang, Yiyuan Cheng, Xiaofeng Wang, Qian Yang,?Wen Liu*. Tracing of acyl carrier protein-channeled mitomycin intermediates in?Streptomyces caespitosus?facilitates characterization of the biosynthetic steps for AHBA？GlcN formation and processing.?Journal of the American Chemical Society?2022,?144(33), 14945-14956.
10.????Zhi Lin#, Yufeng Xue#, Xiao-Wei Liang, Jian Wang, Shuangjun Lin, Jiang Tao, Shu-Li You*,?Wen Liu*. Oxidative indole dearomatization for asymmetric furoindoline synthesis by a flavin-dependent monooxygenase involved in the biosynthesis of bicyclic thiopeptide thiostrepton.?Angewandte Chemie-International Edition?2021,?60(15), 8401-8405.
11.????Bo Pang#, Rijing Liao#, Zhijun Tang#, Shengjie Guo, Zhuhua Wu,?Wen Liu*. Caerulomycin and collismycin antibiotics share a trans-acting flavoprotein-dependent assembly line for 2,2'-bipyridine formation.?Nature Communications?2021,?12, 3124.
12.????Botao Cheng#, Heng Guo#, Haoyang Wang, Qunfei Zhao,?Wen Liu*. Dissection of the enzymatic process for forming a central imidazopiperidine heterocycle in the biosynthesis of a series c thiopeptide antibiotic.?Journal of the American Chemical Society?2021,?143(34), 13790-13797.
13.????Zhijun Tang#; Haoyu Tang#, Wanqiu Wang#, Yufeng Xue, Dandan Chen, Weihua Tang*,?Wen Liu*. Biosynthesis of a new fusaoctaxin virulence factor in?Fusarium graminearum?relies on a distinct path to form a guanidinoacetyl starter unit priming nonribosomal octapeptidyl assembly.?Journal of the American Chemical Society?2021,?143(47), 19719-19730.
14.????Yanping Qiu#, Jingyu Liu#, Yuping Li, Yanqing Xue,?Wen Liu*. Formation of an aminovinyl-cysteine residue in thioviridamides occurs through a path independent of known lanthionine synthetase activity.?Cell Chemical Biology?2021,?28(5), 675-685.
15.????Yanan Du#, Yanping Qu#, Xiang Meng, Junyin Feng, Jiang Tao,?Wen Liu*. A heterotrimeric dehydrogenase complex functions with 2 distinct YcaO proteins to install 5 azole heterocycles into 35-membered sulfomycin thiopeptides.?Journal of the American Chemical Society?2020,?142(18), 8454-8463.
16.????Yike Zou, Song Yang, Jacob N. Sanders, Wei Li, Peiyuan Yu, Hongbo Wang, Zhijun Tang,?Wen Liu*, K. N. Houk*. Computational investigation of the mechanism of Diels-Alderase PyrI4.?Journal of the American Chemical Society?2020,?142(47), 20232-20239.
17.????Daozhong Zhang, Fang Zhang,?Wen Liu*. A KAS-III heterodimer in lipstatin biosynthesis nondecarboxylatively condenses C8 and C14 fatty acyl-CoA substrates by a variable mechanism during the establishment of a C22 aliphatic skeleton.?Journal of the American Chemical Society?2019,?141(9), 3993-4001.
18.????Daozhong Zhang, Zhijun Tang,?Wen Liu*. Biosynthesis of lincosamide antibiotics: reactions associated with degradation and detoxification pathways play a constructive role.?Accounts of Chemical Research?2018,?51(6), 1496-1506.
19.????Qingfei Zheng#, Yukang Gong#, Yujiao Guo, Zhixiong Zhao, Zhuhua Wu, Zixuan Zhou, Dandan Chen, Lifeng Pan*,?Wen Liu*. Structural insights into a flavin-dependent [4+2] cyclase that catalyzes trans-decalin formation in pyrroindomycin biosynthesis.?Cell Chemical Biology?2018,?25(6), 718-727.
20.????Jingjing Li, Yue Li, Guoqing Niu, Heng Guo, Yanping Qiu, Zhi Lin,?Wen Liu*, Huarong Tan*. NosP-regulated nosiheptide production responds to both peptidyl and small-molecule ligands derived from the precursor peptide.?Cell Chemical Biology?2018,?25(2), 143-153.
21.????Guannan Zhong, Qunfei Zhao, Qinling Zhang,?Wen Liu*. 4-Alkyl-L-(dehydro)proline biosynthesis in actinobacteria involves?N-terminal nucleophile-hydrolase activity of γ-glutamyltranspeptidase homolog for C-C bond cleavage.?Nature Communications?2017,?8, 16109.
22.?????Zhi Lin, Jia Ji, Shuaixiang Zhou, Fang Zhang, Jiequn Wu, Yinlong Guo,?Wen Liu*. Processing 2-methyl-L-tryptophan through tandem transamination and selective oxygenation initiates indole ring expansion in the biosynthesis of thiostrepton.?Journal of the American Chemical Society?2017,?139(35), 12105-12108.
23.?????Yanping Qiu#, Yanan Du#, Fang Zhang, Rijing Liao, Shuaixiang Zhou, Chao Peng, Yinlong Guo,?Wen Liu*. Thiolation protein-based transfer of indolyl to a ribosomally synthesized polythiazolyl peptide intermediate during the biosynthesis of the side ring system of nosiheptide.?Journal of the American Chemical Society?2017,?139(50), 18186-18189.
24.?????Zhi Lin, Qingli He,?Wen Liu*. Bio-inspired engineering of thiopeptide antibiotics advances the expansion of molecular diversity and utility.?Current Opinion in Biotechnology?2017,?48, 210-219.
25.?????Qingfei Zheng#, Shoufeng Wang#, Panpan Duan, Rijing Liao, Dandan Chen,?Wen Liu*. An α/β-hydrolase fold protein in the biosynthesis of thiostrepton exhibits a dual activity for endopeptidyl hydrolysis and epoxide ring opening/macrocyclization.?Proceedings of the National Academy of Sciences of the United States of America?2016,?113(50), 14318-14323.
26.?????Bo Pang#, Min Wang#,?Wen Liu*. Cyclization of polyketides and non-ribosomal peptides on and off their assembly lines.?Natural Product Reports?2016,?33(2), 162-173.
27.?????Qingfei Zheng#, Yujiao Guo#, Linlin Yang, Zhixiong Zhao, Zhuhua Wu, Hua Zhang, Jianping Liu, Xiaofang Cheng, Jiequn Wu, Huaiyu Yang, Hualiang Jiang, Lifeng Pan*,?Wen Liu*. Enzyme-dependent [4+2] cycloaddition depends on lid-like interaction of the?N-terminal sequence with the catalytic core in PyrI4.?Cell Chemical Biology?2016,?23(3), 352-360.
28.?????Qingfei Zheng, Zhenhua Tian,?Wen Liu*. Recent advances in understanding the enzymatic reactions of [4+2] cycloaddition and spiroketalization.?Current Opinion in Chemical Biology?2016,?31, 95-102.
29.????Qunfei Zhao#, Min Wang#, Dongxiao Xu, Qinglin Zhang,?Wen Liu*. Metabolic coupling of two small-molecule thiols programs the biosynthesis of lincomycin A.?Nature?2015,?518(7537), 115-119.
30.????Zhenhua Tian#, Peng Sun#, Yan Yan#, Zhuhua Wu, Qingfei Zheng, Shuaixiang Zhou, Hua Zhang, Futao Yu, Xinying Jia, Dandan Chen, Attila Mándi, Tibor Kurtán,?Wen Liu*. An enzymatic [4+2] cyclization cascade creates the pentacyclic core of pyrroindomycins.?Nature Chemical Biology?2015,?11(4), 259-265.
31.????Qingfei Zheng#, Qinglan Wang#, Shoufeng Wang#, Jiequn Wu, Qian Gao*,?Wen Liu*. Thiopeptide antibiotics exhibit a dual mode of action against intracellular pathogens by affecting both host and microbe.?Chemistry & Biology?2015,?22(8), 1002-1007.
32.????Min Wang, Qunfei Zhao,?Wen Liu*. The versatile low-molecular-weight thiols: Beyond cell protection.?Bioessays?2015,?37, 1262–1267.
33.????Heng Guo, Jiang Wang, Yeming Li, Yi Yu, Qingfei Zheng, Jiequn Wu,?Wen Liu*. Insight into bicyclic thiopeptide benefited from development of a uniform approach for molecular engineering and production improvement.?Chemical Science?2014,?5, 240-246.
34.????Yan Yan, Jing Chen, Lihan Zhang, Qingfei Zheng, Ying Han, Hua Zhang, Daozhong Zhang, Takayoshi Awakawa, Ikuro Abe,?Wen Liu*. Multiplexing of combinatorial chemistry in antimycin biosynthesis: expansion of molecular diversity and utility.?Angewandte Chemie-International Edition?2013,?52(47), 12308-12312.
35.?????Peng Sun, Qunfei Zhao, Futao Yu, Hua Zhang, Zhuhua Wu, Yinyan Wang, Yan Wang, Qinglin Zhang,?Wen Liu*. Spiroketal formation and modification in avermectin biosynthesis involves a dual activity of AveC.?Journal of the American Chemical Society?2013,?135(4), 1540-1548.
36.?????Qi Zhang, Bo Pang, Wei Ding,?Wen Liu*. Aromatic polyketides produced by bacterial iterative type I polyketide synthases.?ACS Catalysis?2013,?3(7), 1439-1447.
37.?????Qi Zhang,?Wen Liu*. Biosynthesis of thiopeptide antibiotics and their pathway engineering.?Natural Product Reports?2013,?30(2), 218-226.
38.?????Shoufeng Wang, Shuaixiang Zhou,?Wen Liu*. Opportunities and challenges from current investigations into the biosynthetic logic of nosiheptide-represented thiopeptide antibiotics.?Current Opinion in Chemical Biology?2013,?17(4), 626-634.
39.?????Qiongqiong Wu, Zhuhua Wu, Xudong Qu*,?Wen Liu*. Insights into pyrroindomycin biosynthesis reveal a uniform paradigm for tetramate/tetronate formation.?Journal of the American Chemical Society?2012,?134(42), 17342-17345.
40.????Xudong Qu*, Bo Pang, Zhicong Zhang, Ming Chen, Zhuhua Wu, Qunfei Zhao, Qinglin Zhang, Yinyan Wang, Yun Liu,?Wen Liu*. Caerulomycins and collismycins share a common paradigm for 2,2’-bipyridine biosynthesis via an unusual hybrid polyketide-peptide assembly logic.?Journal of the American Chemical Society?2012,?134(22), 9038-9041.
41.????Qi Zhang, Wilfred A. van der Donk,?Wen Liu*. Radical-mediated enzymatic methylation: a tale of two SAMS.?Accounts of Chemical Research?2012,?45(4), 555-564.
42.????Lian Duan#, Shoufeng Wang#, Rijing Liao,?Wen Liu*. Insights into quinaldic acid formation in thiostrepton biosynthesis facilitating fluorinated thiopeptide generation.?Chemistry & Biology?2012,?19(4), 443-448.
43.????Xudong Qu, Chun Lei,?Wen Liu*. Transcriptome mining of active biosynthetic pathways and their associated products in?Streptomyces flaveolus.?Angewandte Chemie-International Edition?2011,?50(41), 9651-9654.
44.????Qi Zhang, Yuxue Li, Dandan Chen, Yi Yu, Lian Duan, Ben Shen,?Wen Liu*. Radical-mediated enzymatic carbon chain fragmentation-recombination.?Nature Chemical Biology?2011,?7(3), 154-160.
45.????Rijing Liao,?Wen Liu*. Thiostrepton maturation involving a deesterification-amidation way to process the?C-terminally methylated peptide backbone.?Journal of the American Chemical Society?2011,?133(9), 2852-2855.
46.????Yi Yu, Heng Guo, Qi Zhang, Lian Duan, Ying Ding, Rijing Liao, Chun Lei, Ben Shen,?Wen Liu*. NosA catalyzing carboxyl-terminal amide formation in nosiheptide maturation via an enamine dealkylation on the serine-extended precursor peptide.?Journal of the American Chemical Society?2010,?132(46), 16324-16326.
47.????Wei Ding, Chun Lei, Qingli He, Qinglin Zhang, Yurong Bi,?Wen Liu*. Insights into bacterial 6-methylsalicylic acid synthase and its engineering to orsellinic acid synthase for spirotetronate generation.?Chemistry & Biology?2010,?17(5), 495-503.
48.????Rijing Liao, Lian Duan, Chun Lei, Haixue Pan, Ying Ding, Qi Zhang, Daijie Chen, Ben Shen, Yi Yu*,?Wen Liu*. Thiopeptide biosynthesis featuring ribosomally synthesized precursor peptides and conserved posttranslational modifications.?Chemistry & Biology?2009,?16(2), 141-147.
49.????Qunfei Zhao, Qingli He, Wei Ding, Mancheng Tang, Qianjin Kang, Yi Yu, Wei Deng, Qi Zhang, Jie Fang, Gongli Tang,?Wen Liu*. Characterization of the azinomycin B biosynthetic gene cluster revealing a different iterative type I polyketide synthase for naphthoate biosynthesis.?Chemistry & Biology?2008,?15(7), 693-705.
50.????Xin-Ying Jia, Zhen-Hua Tian, Lei Shao, Xu-Dong Qu, Qun-Fei Zhao, Jian Tang, Gong-Li Tang*,?Wen Liu*. Genetic characterization of the chlorothricin gene cluster as a model for spirotetronate antibiotic biosynthesis.?Chemistry & Biology?2006,?13(6), 575-585.
