

文留青,獲得微生物學(xué)和化學(xué)雙碩士學(xué)位,化學(xué)博士學(xué)位。2019年加入上海藥物所,任研究員,課題組長。主要從事糖化學(xué)生物學(xué)和糖類藥物研究。以通訊作者或者共同通訊作者身份在ACS Central Science、Chemical Reviews、J. Am. Chem. Soc.、 Angew. Chem. Int. Ed.、ACS catalysis等雜志發(fā)表多篇研究論文。獲得2016年佐治亞州立大學(xué)化學(xué)系年度優(yōu)秀研究生,2017年國家優(yōu)秀自費留學(xué)生獎學(xué)金?;貒笙群螳@得上海市,中科院和國家的基金支持。
工作經(jīng)歷
2017.5–2019.8 佐治亞州立大學(xué),博士后
2019.9至今 中國科學(xué)院上海藥物研究所,研究員 ,課題組長
基于寡糖的藥物研究和新藥靶點發(fā)現(xiàn)
2016 佐治亞州立大學(xué)化學(xué)系年度優(yōu)秀研究生? ?
2017 國家優(yōu)秀自費留學(xué)生獎學(xué)金
(*corresponding author)
(6) Wang, S; Zhang, J; Wei, F; Li, W; Li, W;?Wen, L.* Facile Synthesis of Sugar Nucleotides from Common Sugars by Cascade Conversion Strategy.?J. Am. Chem. Soc. 2022 (Accept).
(5) Ma, W.; Deng, Y.; Xu, Z.; Liu, X.; Chapla, D. G.; Moremen, K. W.;?Wen, L.; Li, T.*? Integrated Chemoenzymatic Approach to Streamline the Assembly of Complex Glycopeptides in the Liquid Phase.?J. Am. Chem. Soc.?2022, Online.
(4) Zheng, Y.; Zhang, J.; Meisner, J.; Li, W.; Luo, Y.; Wei, F.;?Wen, L.* Cofactor-Driven Cascade Reactions Enable the Efficient Preparation of Sugar Nucleotides.?Angew. Chem. Int. Ed. 2022, 61 (20)
(3) Tian, Y.; Zhu, Q.; Sun, Z.; Geng, D.; Lin, B.; Su, X.; He, J.; Guo, M.; Xu, H.; Zhao, Y.; Qin, W.; Wang, P. G.;?Wen, L.; Yi, W.* One-Step Enzymatic Labeling Reveals a Critical Role of O-GlcNAcylation in Cell-Cycle Progression and DNA Damage Response.?Angew. Chem. Int. Ed. 2021, 60 (50), 26128-26135.
(2) Xu, Z.; Deng, Y.; Zhang, Z.; Ma, W.; Li, W.;?Wen, L.;*? Li, T.*, Diversity-Oriented Chemoenzymatic Synthesis of Sulfated and Nonsulfated Core 2 O-GalNAc Glycans.?J. Org. Chem.?2021, 86 (15), 10819-10828.
(1) Zhang, J.; Liu, D.; Saikam, V.; Gadi, M. R.; Gibbons, C.; Fu, X.; Song, H.; Yu, J.; Kondengaden, S. M.; Wang, P. G.;?Wen, L.*?Machine-Driven Chemoenzymatic Synthesis of Glycopeptide.?Angew. Chem. Int. Ed.?2020, 59 (45), 19825-19829.
Before 2019 (*corresponding author)
(13) Zhang, J.; Chen, C.; Gadi, M. R.; Gibbons, C.; Guo, Y.; Cao, X.; Edmunds, G.; Wang, S.; Liu, D.; Yu, J.;?Wen, L.;* Wang, P. G.,* Machine-Driven Enzymatic Oligosaccharide Synthesis by Using a Peptide Synthesizer.?Angew. Chem. Int. Ed. 2018, 57 (51), 16638-16642.
?12.?Wen, L. Q.*; Gadi, R. M.; Zheng, Y.; Gibbons, C.; Kondengaden, S. M.; Zhang, J. B.; Wang, P. G.* Chemoenzymatic Synthesis of Unnatural Nucleotide Sugars for Enzymatic Biorthogonal Labeling.?ACS Catal. 2018, 8 (8), 7659-7666.?
11.?Wen, L.?Q. #*; Edmunds, G. #; Gibbons, C. #; Zhang, J. B. #; Gadi, M. R.; Zhu, H. L.; Fang, J. Q.; Liu, X. W.; Kong, Y.; Wang, P. G.* Toward Automated Enzymatic Synthesis of Oligosaccharides. 2018,?Chem. Rev.?2018, 118, 17, 8151?
10.?Wen, L. Q.*; Zheng, Y.; Huang, K.; Song, J.; Wang, P. G.* A One-step Chemoenzymatic Labeling Strategy for Probing Sialylated Thomsen?Friedenreich Antigen.?ACS Centra. Sci, 2018, 4, 451451?
9.?Wen, L. Q.; Zheng, Y.; Jiang, K.; Zhang, M. Z.; Kondengaden, S. M.; Li, S. S.; Huang, K.; Li, J.; Song, J.; Wang, P. G. Two-Step Chemoenzymatic Detection of N-Acetylneuraminic Acid-alpha(2-3)-Galactose Glycans.? J. Am. Chem. Soc. 2016, 138, 11473.?
8.? Liu, Y. P.; #?Wen, L. Q.; # Li, L.; Gadi, M. R.; Guan, W. Y.; Huang, K.; Xiao, Z. Y.; Wei, M. H.; Ma, C.; Zhang, Q.; Yu, H.; Chen, X.; Wang, P. G.; Fang, J. Q. A General Chemoenzymatic Strategy for the Synthesis of Glycosphingolipids.?Eur. J. Org. Chem. 2016, 4315. (contribute equally)?
7.?Wen, L. Q. *; Huang, K.; Zheng, Y.; Fang, J. Q.; Kondengaden, S. M.; Wang, P. G. * Two-step enzymatic synthesis of 6-deoxy-L-psicose.?Tetrahedron Lett.?2016, 57, 3819.?
6.???Wen, L. Q.; Huang, K.; Zheng, Y.; Liu, Y. P.; Zhu, H.; Wang, P. G. A two-step strategy for the preparation of 6-deoxy-l-sorbose. Bioorg.?Med. Chem. Lett.?2016, 26, 218.?
5.? ?Wen, L.?Q.; Zheng, Y.; Li, T. H.; Wang, P. G. Enzymatic synthesis of 3-deoxy-d-manno-octulosonic acid (KDO) and its application for LPS assembly. Bioorg.?Med. Chem. Lett. 2016, 26, 2825.?
4.??Wen, L.?Q.; Huang, K.; Liu, Y. P.; Wang, P. G. Facile Enzymatic Synthesis of Phosphorylated Ketopentoses. ACS. Catal. 2016, 6, 1649.?
3.??Wen, L. Q.; Zang, L. L.; Huang, K.; Li, S. S.; Wang, R. L.; Wang, P. G. Efficient enzymatic synthesis of L-rhamnulose and L-fuculose.?Bioorg. Med. Chem. Lett. 2016, 26, 969.?
2.??Wen, L. Q.; Huang, K.; Wei, M. H.; Meisner, J.; Liu, Y. P.; Garner, K.; Zang, L. L.; Wang, X.; Li, X.; Fang, J. Q.; Zhang, H. C.; Wang, P. G. Facile Enzymatic Synthesis of Ketoses. Angew. Chem. Int. Ed. 2015, 54, 12654.?
1.? Li, T. H.; #?Wen, L. Q.; # Williams, A.; Wu, B. L.; Li, L.; Qu, J. Y.; Meisner, J.; Xiao, Z. Y.; Fang, J. Q.; Wang, P. G. Chemoenzymatic synthesis of ADP-d-glycero-beta-d-manno-heptose and study of the substrate specificity of HldE.?Biorg. Med. Chem.?2014, 22, 1139.