

2019年11月至今:中科院上海有機化學研究所生物與化學交叉研究中心?研究員、課題組長
2016年11月-2019年11月:?哈佛大學醫(yī)學院?博士后
2016年6月-2016年10月:?中科院上海有機化學研究所?助理研究員
2011年9月-2016年06月:?中科院上海有機化學研究所?博士
2007年9月-2011年06月:?浙江大學?學士
細胞生物學和化學生物學;
細胞死亡、炎癥和內(nèi)穩(wěn)態(tài)失調(diào)的調(diào)控機制以及在人類疾病中的作用;
衰老和神經(jīng)退行性疾病的調(diào)控機理;
蛋白翻譯后修飾及其生理病理功能
2011???浙江大學竺可楨特優(yōu)畢業(yè)生
2012-2014???中國科學院大學“三好學生”
2015????冷泉港亞洲獎學金
1.?Xu D, Jin T, Zhu H, Chen H, Ofengeim D, Zou C, Mifflin L, Pan L, Amin P, Li W, Shan B, Naito M, Geng J, Meng H, Li Y, Pan H, Aron L, Adiconis X, Levin J, Yankner B, Yuan J. TBK1 suppresses RIPK1-driven apoptosis and inflammation during development and in aging.?Cell. 2018, 174(6):1477.
2.?Xu D, Liu J, Fu T, Shan B, Qian L, Pan L, Yuan J. USP25 regulates Wnt signaling by controlling the stability of tankyrases.?Genes Dev. 2017, 31(10):1024.
3.?Xu D, Shan B, Sun H, Xiao J, Zhu K, Xie X, Li X, Liang W, Lu X, Qian L, Yuan J. USP14 regulates autophagy by suppressing K63 ubiquitination of Beclin 1.?Genes Dev. 2016. (15):1718.
4.?Xu D, Shan B, Lee BH, Zhu K, Zhang T, Sun H, Liu M, Shi L, Liang W, Qian L, Xiao J, Wang L, Pan L, Finley D, Yuan J. Phosphorylation and activation of ubiquitin-specific protease-14 by Akt regulates the ubiquitin-proteasome system.?Elife. 2015, 4:e10510.
5.?Xu D, Zhang T, Xiao J, Zhu K, Wei R, Wu Z, Meng H, Li Y, Yuan J. Modification of BECN1 by ISG15 plays a crucial role in autophagy regulation by type I IFN/interferon.?Autophagy. 2015, 11(4):617.
6.?Xu D, Lv C, Chen W. Palladium-catalyzed double arylations of terminal olefins in acetic acid.?Tetrahedron, 2012, 68(5):1466.
7. Naito M,?Xu D, Amin P, Lee J, Wang H, Li W, Kelliher M, Pasparakis M, Yuan J. Sequential activation of necroptosis and apoptosis cooperates to mediate vascular and neural pathology in stroke.?PNAS. 2020, 117(9):4959.
8. Zhu K, Liang W, Ma Z,?Xu D, Cao S, Lu X, Liu N, Shan B, Qian L, Yuan J. Necroptosis promotescell-autonomous activation of proinflammatory cytokine gene expression.?Cell Death Dis. 2018, 9(5):500.
9. Li F,?Xu D, Wang Y, Zhou Z, Liu J, Hu S, Gong Y, Yuan J, Pan L. Structural insights into the ubiquitin recognition by OPTN (optineurin) and its regulation by TBK1-mediated
phosphorylation.?Autophagy. 2018, 14(1):66.
10. Geng J, Ito Y, Shi L, Amin P, Chu J, Ouchida AT, Mookhtiar AK, Zhao H,?Xu D, Shan B, Najafov A, Gao G, Akira S, Yuan J. Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis.?Nat Commun. 2017, 8(1):359.
11. Zhang T, Dong K, Liang W,?Xu D, Xia H, Geng J, Najafov A, Liu M, Li Y, Han X, Xiao J, Jin Z, Peng T, Gao Y, Cai Y, Qi C, Zhang Q, Sun A, Lipinski M, Zhu H, Xiong Y, Pandolfi PP, Li H, Yu Q, Yuan J. G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L.?Elife. 2015, 4:e06734.
12. Xiao J, Zhang T,?Xu D, Wang H, Cai Y, Jin T, Liu M, Jin M, Wu K, Yuan J. FBXL20-mediated Vps34 ubiquitination as a p53 controlled checkpoint in regulating autophagy and receptor degradation.?Genes Dev. 2015, 29(2):184.
13. Liu B, Zhang Y,?Xu D, Chen W. Facile synthesis of metal N-heterocyclic carbene complexes.?Chem Commun, 2011, 47(10):2883.
14. Gu S,?Xu D, Chen W. Heterobimetallic complexes containing an N-heterocyclic carbene based multidentate ligand and catalyzed tandem click/Sonogashira reactions.?Dalton Trans. 2011, 40(7):1576.